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Highly potent, selective inhibitor of vacuolar type H+-ATPase (V-ATPase). Selective for V-ATPase over other ATP hydrolyzing enzymes such as F-ATPases and the H+/K+-ATPase (P-ATPase). Lysosomal proton pump inhibitor. Autophagy inhibitor - either by blocking autophagosome-lysosome fusion or by blocking lysosomal degradation.
C35H58O9
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