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DPc10 Peptide

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产品名称: DPc10 Peptide
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产品展商: Badrilla
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简单介绍

DPc10 Peptide


DPc10 Peptide  的详细介绍
DPc10 Peptide

DPc10 Peptide

$158.49

In stock

Product code: A010-514
Unit Size: 200µg net peptide
  • Description
  • Data Sheet

GFCPDHKAAMVLFLDRVYGIEVQDFLLHLLEVGFLP

DPc10 peptide is a 36-residue peptide corresponding to the Gly2460-Pro2495 region of rabbit RyR2. It interacts with RyR2 and provokes abnormal channel activity usually seen in mutant RYR2 channels associated with CPVT. This peptide can be used to provoke pathological RyR2 behaviour in wild-type RyR2 channels. The peptide binds at an interface between domains of RYR2, “unzipping” these domains and altering channel function. The DPc10 is preserved in RYR2 from all mammalian species.

DPc10 (0.5-5 µM) elevates Ca2+-leak, increases Ca2+-spark activity, is pro-arrhythmic, and provokes hypertrophy in cardiac myocytes.

DPc10 in the current form is not cell permeable. The product is useful in applications that permit access to RyR2 directly (via whole cell patch, skinned cells, black lipid membrane, vesicles, or upon delivery to cytoplasm).

 Read DPc10 Publications

Peptide name

DPc10

Peptide sequence

GFCPDHKAAMVLFLDRVYGIEVQDFLLHLLEVGFLP

N-terminus

Amine

C-terminus

Acid

Counter ions

Trifluroacetate (TFA)

Molecular weight

4103.835

HPLC analysis

Analysis carried out using a 100A 4.6 x 150mm column, gradient from 10% - 90% Acetonitrile, in 15 minutes. Peptide Dissolved in DMSO. Purity determined as 97.28%.

MS analysis

Molecular ion predicted: 4103.835 observed: 4103.835

Appearance

Lyophilised off-white solid

Solubilisation

DMSO

Storage

Store as supplied at -20°C for up to 1 year. Store desiccated. Make fresh solutions prior to use.

Datasheet A010-514

Read DPc10 Publications

MSDS A010-514

Notes

The product was purified in acetonitrile and water containing 0.1% trifluoroacetic acid (TFA) prior to lyophilisation. The product will therefore be present as its trifluoroacetic acid salt.

*Peptide is supplied by net peptide weight.  Whilst the purity of the material has been shown to be >95%, the net peptide content is lower due to counterions and residual water present in the material.  To compensate for this the amount of peptide weighed out is adjusted so that the amount of active material received is exactly as stated on the vial.  This means that the total mass will be in excess of 200µg, but there will be exactly 200µg of the active peptide in the vial. The remainder of the weight is due to the counter ions and residual water.

Regulatory statement Product for research use only. Not intended for diagnostic or therapeutic use.
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