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Ryanodine receptor 2 (RYR2) (pSer2030) pAb

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产品名称: Ryanodine receptor 2 (RYR2) (pSer2030) pAb
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产品展商: Badrilla
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Ryanodine receptor 2 (RYR2) (pSer2030) pAb


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Ryanodine receptor 2 (RYR2) (pSer2030) pAb
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Ryanodine receptor 2 (RYR2) (pSer2030) pAb

$599.00

In stock

Product code: A010-32
Unit Size: 50 µl
  • Description
  • Data Sheet

A fully validated, highly specific rabbit polyclonal anti-serum to Serine-2030 phosphorylated Ryanodine Receptor

The ryanodine receptor (RyR2) is a Ca2+ channel of cardiac muscle that plays a central role in EC coupling. The binding of Ca2+ to RyR2 opens the channel and Ca2+ stored in the SR moves through the channel into the cytosol to initiate muscle contraction. PKA, and not CaMKII, was able to phosphorylate Ser-2030 of RYR2 in vitro and in isolated cardiac myocyte cells.

Tested applications: Western blot (1:5000 dilution). Species recognition: human, rat, mouse, rabbit, canine and sheep. 

 

 
Description Lyophilised Rabbit polyclonal anti-serum containing IgG antibody specific for Ser-2030 (PKA) phosphorylated RYR2.
Immunogen Synthetic peptide (TIRGRLLS(PO3H2)LVE2033) corresponding to amino acids surrounding the phosphorylated serine residue at position 2030 of RYR2 (human), conjugated to KLH.
Isotype IgG
Purification Raw serum
Species reactivity The antibody recognises RYR2 phosphorylated at serine 2030 and binding is blocked in the presence of a peptide containing the phospho-Ser2030 epitope.
Tested applications WB
Recommended dilution WB 1:1000
Optimization Optimal dilutions to be determined by end user
Storage Lyophilised antibody is stable at 4 °C when stored with desiccant. Reconstitute lyophilised powder in 50 µl of 18 MΩ H2O, aliquot and store frozen at -80 °C for 1 year. Avoid freeze - thaw cycles.
Storage Lyophilised: 4 °C. Reconstituted:-80 °C
Datasheet A010-32
MSDS A010-32
Regulatory statement Product for research use only. Not intended for diagnostic or therapeutic use.
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