A fully validated, highly specific affinity purified rabbit polyclonal antibody to Serine-2814 phosphorylated Ryanodine Receptor

The Ryanodine Receptor (RyR2) is a Ca2+ channel of cardiac muscle that plays a central role in EC coupling. The binding of Ca2+ to ryanodine receptor 2 RyR2 opens the channel and Ca2+ stored in the SR moves through the channel into the cytosol to initiate muscle contraction. CaMKII, was able to phosphorylate Ser-2814 of RYR2 enhancing Ca2+- sensitivity and increasing open probability. Excessive phosphorylation of Ser-2814 leads to atrial fibrillation, arrhythmias and sudden death.

Tested applications: Western blot (1:1000 dilution). Species recognition: All mammalian species, when phosphorylated on Ser-2814 (or Ser-2815 rabbit).