Highly specific, well validated polyclonal antiserum to SERCA2a

 SERCA2a is a Ca²⁺ pump located in the sarcoplasmic reticulum of cardiac and slow-twitch skeletal muscle. The enzyme transports Ca²⁺ from the cytoplasm into the SR using the hydrolysis of ATP as the energy source for this reaction. Two Ca²⁺ are transported for each ATP hydrolysed.  This Ca²⁺ transport is the principal means of muscle relaxation in cardiac and slow-twitch skeletal muscle. The activity of SERCA2a is moderated by its interaction with phospholamban. SERCA2a is one isoform of SERCA2: this isoform differs from SERCA2b and SERCA2c at the extreme carboxy terminus only.  Antibody A010-20 recognises the C-terminal sequence which distinguishes SERCA2a from SERCA2b and SERCA2c. 

Tested applications: Western Blot (1:5000 dilution). Species recognition: The antibody reacts with SERCA2a from human, rat, mouse, rabbit, canine, and bovine species.