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HistoneH3K36me2PolyclonalAntibody

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产品名称: HistoneH3K36me2PolyclonalAntibody
产品型号: A70017-5
产品展商: 其它品牌
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发布时间:2020-05-25

简单介绍

HistoneH3K36me2PolyclonalAntibody


HistoneH3K36me2PolyclonalAntibody  的详细介绍
Product Information
Purity: Affinity purification
Storage: Store at -20 or -80°C. Avoid freeze/thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Catalog No: A70017

Histone H3K36me2 Polyclonal Antibody

Application:

WB (1:500-1:2000), IF (1:50-1:200), IHC (1:50-1:200)

Cross-Reactivity: Eukaryotes

Calculated MW: 15kDa

Species: Rabbit

Isotype: IgG

Purity: Affinity purification

Concentration: 1mg/mL

Storage:

Store at -20 or -80°C. Avoid freeze/thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Immunogen Information

Immunogen:

A synthetic methylated peptide corresponding to residues surrounding Lys36 of human histone H3

Gene ID: 8290

Swiss Prot: Q16695

Synonyms:

HIST1H3J; H3/j; H3FJ; Histone H3.1; Histone H3/a; Histone H3/b; Histone H3/c; Histone H3/d; Histone H3/f; Histone H3/h; Histone H3/I; Histone H3/j; Histone H3/k; Histone H3/I; HIST3H3

Background:

H3K36 methylation is known as one of the gene activation makers. Several enzymes from yeast and humans, including the methyltransferases SET domain-containing 2 (Set2) and nuclear receptor SET domain-containing 1 (NSD1), respectively, alter the methylation status of H3K36, and significant progress has been made in understanding how they affect chromatin structure and function. Although H3K36 methylation is most commonly associated with the transcription of active euchromatin, it has also been implicated in diverse processes, including alternative splicing, dosage compensation and transcriptional repression, as well as DNA repair and recombination. Disrupted placement of methylated H3K36 within the chromatin landscape can lead to a range of human diseases, underscoring the importance of this modification (1).

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SDS:

Reference:

1. Wagner EJ, et al. Understanding the language of Lys36 methylation at histone H3. (2012) Nat Rev Mol Cell Biol. 23;13(2):115-26

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