HDAC4 Mouse Monoclonal Antibody
Alt. Names
HD4; HDACA; HA6116; HDAC-A; KIAA0288; HDAC4
Specificity:
HDAC4 antibody detects endogenous levels of total HDAC4
Purification:
Affinity-chromatography
Immunogen:
Purified recombinant fragment of human HDAC4 expressed in E. Coli
Storage Condition and Buffer:
Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Histone deacetylase 4 (HDAC4) is a histone deacetylase that represses transcription when tethered to a promoter. It has been shown to interact with MEF2C, Zinc finger, CBX5, Nuclear receptorco-repressor1 and HDAC3 (1, 2, 3, 4, 5). In neurological findings, HDAC4 has been shown to shuttle between the nucleus and cytoplasm, controlling a transcriptional program essential for synaptic plasticity and memory. The nuclear import of HDAC4 represses genes encoding constituents of central synapses, thereby affecting synaptic architecture and strength (6).
Reference:
Product is for research use only. Not for human use.
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