产品资料

HDAC4MouseMonoclonalAntibody

如果您对该产品感兴趣的话,可以
产品名称: HDAC4MouseMonoclonalAntibody
产品型号: A90011-5
产品展商: 其它品牌
产品文档: 无相关文档

简单介绍

HDAC4MouseMonoclonalAntibody


HDAC4MouseMonoclonalAntibody  的详细介绍
Product Information

HDAC4 Mouse Monoclonal Antibody

Clonality: Monoclonal Source: Mouse  
Cross-Reactivity: Human    
Concentration: 100 ug/100 ul Detected band  (by western) MW: 119KD  
Applications: WB: 1:500-1:2000 ELISA 1/10000  

Alt. Names

HD4; HDACA; HA6116; HDAC-A; KIAA0288; HDAC4

Specificity:

HDAC4 antibody detects endogenous levels of total HDAC4

Purification:

Affinity-chromatography

Immunogen:

Purified recombinant fragment of human HDAC4 expressed in E. Coli

Storage Condition and Buffer:

Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt. 

Background:

Histone deacetylase 4 (HDAC4) is a histone deacetylase that represses transcription when tethered to a promoter.  It has been shown to interact with MEF2C, Zinc finger, CBX5, Nuclear receptorco-repressor1 and HDAC3 (1, 2, 3, 4, 5).  In neurological findings, HDAC4 has been shown to shuttle between the nucleus and cytoplasm, controlling a transcriptional program essential for synaptic plasticity and memory.  The nuclear import of HDAC4 represses genes encoding constituents of central synapses, thereby affecting synaptic architecture and strength (6). 

PDF:

SDS:

Reference:

  1. Wang, A H et al.  HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressors. (1999) Mol. Cell. Biol (UNITED STATES) 19 (11): 7816–27.
  2. Anne C et al. HDAC4 mediates transcriptional repression by the acute promyelocytic leukaemia-associated protein PLZF". (2004) Oncogene (England) 23 (54): 8777–84.
  3. Olson E N et al. Association of class II histone deacetylases with heterochromatin protein 1: potential role for histone methylation in control of muscle differentiation. (2002) Mol. Cell. Biol. (United States) 22 (20): 7302–12.
  4. Wolfgang F et al. Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR". (2002) Mol. Cell (United States) 9 (1): 45–57.
  5. Fischle, W et al. Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo. (2001) J. Biol. Chem. (United States) 276
  6. Sando, R et al. HDAC4 Governs a Transcriptional Program Essential for Synaptic Plasticity and Memory. (2012) Cell. 151 (4): 821-834. 

Product is for research use only. Not for human use.

产品留言
标题
联系人
联系电话
内容
验证码
点击换一张
注:1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
2.如有必要,请您留下您的详细联系方式!

沪公网安备 31011202007337号