Alt. Names
H3 histone antibody, HIST1H3A antibody, Histone cluster 1, H3a antibody
Specificity:
The Histone H3 (tri methyl K36) mouse monoclonal antibody can recognize endogenous Histone H3 (tri methyl K36) proteins.
Immunogen:
Mouse monoclonal antibody is prepared by immunizing synthetic peptide coupled to KLH.
Storage Condition and Buffer:
Store at -20°C. Stable for one year from the date of shipment. 1mg/ml in PBS, pH 7.4, containing 0.02% sodium azide and 50% glycerol
H3K36 methylation is known as one of the gene activation makers. Several enzymes from yeast and humans, including the methyltransferases SET domain-containing 2 (Set2) and nuclear receptor SET domain-containing 1 (NSD1), respectively, alter the methylation status of H3K36, and significant progress has been made in understanding how they affect chromatin structure and function. Although H3K36 methylation is most commonly associated with the transcription of active euchromatin, it has also been implicated in diverse processes, including alternative splicing, dosage compensation and transcriptional repression, as well as DNA repair and recombination. Disrupted placement of methylated H3K36 within the chromatin landscape can lead to a range of human diseases, underscoring the importance of this modification. (1)
Reference:
1. Wagner EJ, et al. Understanding the language of Lys36 methylation at histone H3. (2012) Nat Rev Mol Cell Biol. 23;13(2):115-26
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