BMI1MouseMonoclonalAntibody

Alt. Names

H3 histone antibody, HIST1H3A antibody, Histone cluster 1, H3a antibody

Specificity:

BMI1 antibody detects endogenous levels of total BMI1

Immunogen:

Purified recombinant fragment of human BMI1 expressed in E. Coli

Purification:

Affinity-chromatography

Storage Condition and Buffer:

Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.

Polycomb complex protein BMI-1 is found a canonical self-renewal regulator. Tumor Formation and, more specifically, human colorectal cancer-initiating cells (CIC) are dependent on BMI-1.  Down-regulation of BMI-1 inhibits the ability of colorectal CICs to self-renew, resulting in the abrogation of their tumorigenic potential.  Targeting the BMI-1 self-renewal machinery represents a promising approach to the elimination of many cancer stem (and initiating) cells. 

BIMI-1 antibody detects endogenous levels of total BMI-1, thus a good tool of BMI-1 related cancer study.

Please refer PDF file for Western, Immunofluorescence analysis,Chromatin immunoprecipitation analysis or other QC data.

Reference:

1. Kreso A, et al.  Self-renewal as a therapeutic target in human colorectal cancer. (2014) Nat Med. (1):29-36. 

Product is for research use only. Not for human use.

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