主营产品: ad检测试剂盒,agc试剂盒,akt试剂盒,ald检测试剂盒,ctc试剂盒,hp试剂盒,apo试剂盒,chip试剂盒,mmp试剂盒,酶联免疫,酶联免疫ELISA,酶联免疫法,elisa原理,酶联免疫试剂盒,elisa酶免试剂盒,Antibody,抗体
产品详情

WS3,βCellProliferationInducer

如果您对该产品感兴趣的话,可以
产品名称: WS3,βCellProliferationInducer
产品型号: M60095-2s
产品展商: 其它品牌
美元($)价格: 139.00 元
欧元(€)价格: 0.00 元
人民币(¥)价格: 0.00 元
产品文档: 无相关文档
发布时间:2020-06-29

简单介绍

WS3,βCellProliferationInducer


WS3,βCellProliferationInducer  的详细介绍
Product Information
Molecular Weight: 569.58
Formula: C28H30F3N7O3
Purity: ≥ 98%
CAS#: 1421227-52-2
Solubility: DMSO up to 100 mM
Chemical Name: N-(6-(4-(3-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)ureido)phenoxy)pyrimidin-4-yl)cyclopropanecarboxamide
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

Biological Activity:
WS3 is a highly potent and selective small molecule that promotes pancreatic β cell and RPE cells expansion, identified by a high-throughput, cell-based screening. It can induce proliferation of mouse R7T1 β cells with an EC50 ~0.074 µM, and expansion of primary rat and human β cells in dissociated and intact islet format with similar EC50. WS3 can also reversibly proliferate primary RPE cells isolated from fetal and ***** human donors. Following withdrawal of WS3, RPE cells differentiate into a functional monolayer, as exhibited by their expression of mature RPE genes and phagocytosis of photoreceptor outer segments. Furthermore, chemically expanded RPE cells preserve vision when transplanted into dystrophic Royal College of Surgeons (RCS) rats, a well-established model of retinal degeneration.

 

How to Use:

  • In vitro: WS3 was used at 0.05-0.2 µM concentration in beta cell proliferation *****s in vitro. WS3 was used at 25 nM concentration in RPE cells expansion *****s. 
  • In vivo: n/a

 

Reference:

  • 1. Shen W, et al. Small-Molecule Inducer of β Cell Proliferation Identified by High-Throughput Screening. (2013) J Am Chem Soc. 135(5):1669-72.
  • 2. Swoboda JG, et al. Small Molecule Mediated Proliferation of Primary Retinal Pigment Epithelial Cells. (2013) ACS Chem Biol. In press. 

 


Products are for research use only. Not for human use.

产品留言
标题
联系人
联系电话
内容
附件:
附件支持RAR,JPG,PNG格式,大小在2M范围,只允许上传1个
验证码
点击换一张
注:1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
2.如有必要,请您留下您的详细联系方式!
Copyright@ 2003-2020  上海拜力生物科技有限公司  版权所有  

本公司网站所展示销售的产品仅供科研!

            

沪公网安备 31011202007337号