Biological Activity:Verteporfin (Visudyne) is a potent and selective YAP inhibitor, disrupts YAP-TEAD interactions and enhances trypsin cleavage of YAP with EC50 ~100 nM. It inhibits growth and proliferation of retinoblastoma cells. It also significantly blocks cancer stem cell (CSC) properties in cells with high YAP1 and a high proportion of ALDH1(+). In vivo it can suppress YAP-induced liver overgrowth in mice.How to Use:In vitro: Verteporfin was used at 10 µM final concentration in various in vitro assays.In vivo: Verteporfin was administered by intraperitoneal injection at 100 mg/Kg once every other day in liver overgrowth model.Reference:
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