Biological Activity:TAME is a competitive inhibitor of the ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C). It promotes Cdc20 autoubiquitination and inhibits cyclin proteolysis in mitotic Xenopus oocyte extracts (IC50 ~ 12 μM) and blocks cyclin degradation in interphase extract.How to Use:In vitro: TAME was used at 50-200 µM final concentration in various in vitro assays.In vivo: n/aReference:
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