Biological Activity:
PYR-41 is a specific and cell permeable inhibitor of ubiquitin-activating enzyme E1 with an IC50 of < 10 uM, with no or little activity against E2. It blocks ubiquitylation and prevents ubiquitin-mediated proteasomal degradation. It inhibits NF-κB activation, blocks degradation of p53, increases p21 levels and induces apoptosis in vitro. PYR-41 can also cause an increase in sumoylation of proteins.
How to Use:
Reference:
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