PFI-2,SETD7HistoneLysineMethyltransferaseInhibitor

点击看大图

如果您对该产品感兴趣的话,可以

产品名称: PFI-2,SETD7HistoneLysineMethyltransferaseInhibitor

产品型号: M60182-2s

产品展商: 其它品牌

产品文档: 无相关文档

简单介绍

PFI-2,SETD7HistoneLysineMethyltransferaseInhibitor

PFI-2,SETD7HistoneLysineMethyltransferaseInhibitor 的详细介绍

Product Information

Molecular Weight:	499.52
Formula:	C₂₃H₂₅F₄N₃O₃S
Purity:	≥98%
CAS#:	1627676-59-8
Solubility:	DMSO up to 100 mM
Chemical Name:	(R)-8-fluoro-N-(1-oxo-1-(pyrrolidin-1-yl)-3-(3-(trifluoromethyl)phenyl)propan-2-yl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide
Storage:	Powder: 4^oC 1 year. DMSO: 4^oC 3 month; -20^oC 1 year.

Biological Activity:
PFI-2 is a novel potent and selective SETD7 histone lysine methyltransferase inhibitor with IC₅₀ ~2 nM. It has > 100-fold selectivity over other methyltransferases and other non-epigenetic targets. PFI-2 has been shown to bind to SETD7 by ITC (Kd=18nM), and biotinylated PFI-2 interacts with SETD7 in pull-down studies.

How to Use:

In vitro: PFI-2 was used at 1 µM in vitro.
In vivo: n/a

Reference:

1. http://www.thesgc.org/chemical-probes/epigenetics

Products are for research use only. Not for human use.

产品留言

标题

联系人

联系电话

内容

验证码

点击换一张

注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
2.如有必要,请您留下您的详细联系方式!