OF-1,BRPFBromodomainInhibitor

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产品名称: OF-1,BRPFBromodomainInhibitor

产品型号: M60222-2s

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简单介绍

OF-1,BRPFBromodomainInhibitor

OF-1,BRPFBromodomainInhibitor 的详细介绍

Product Information

Molecular Weight:	440.31
Formula:	C₁₇H₁₈BrN₃O₄S
Purity:	≥98%
CAS#:	919973-83-4
Solubility:	DMSO up to 20 mM
Chemical Name:	4-bromo-N-(6-methoxy-1,3-dimethyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)-2-methylbenzenesulfonamide
Storage:	Powder: 4^oC 1 year. DMSO: 4^oC 3 month; -20^oC 1 year.

Biological Activity:

OF-1 is the potent and selective BRPF (BRomodomain and PHD Finger containing) inhibitor. It binds to BRPF1B with a KD of 100 nM (ITC), to BRPF2 with a KD of 500 nM (ITC) and to BRPF3 with a KD of 2.4 mM (ITC). It has general >100-fold selectivity against other bromodomains (39-fold selectivity over BRD4). OF-1 increases thermal stability in the cellular thermal shift assay (CETSA) of full length BRPF1B at 1 µM and also demonstrates accelerated FRAP recovery at 5 µM in the BRPF2 FRAP assay. It shows modest general cytotoxicity.

How to Use:

In vitro: OF-1 was used at 5-10 µM final concentration in various in vitro assays.
In vivo: n/a

Reference

http://www.thesgc.org/chemical-probes/OF-1

ProProducts are for research use only. Not for human use.

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