NSC636819,KDM4A/KDM4BInhibitor

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产品名称: NSC636819,KDM4A/KDM4BInhibitor

产品型号: M60290-2s

产品展商: 其它品牌

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简单介绍

NSC636819,KDM4A/KDM4BInhibitor

NSC636819,KDM4A/KDM4BInhibitor 的详细介绍

Product Information

Molecular Weight:	510.15
Formula:	C₂₂H₁₂Cl₄N₂O₄
Purity:	≥98%
CAS#:	1618672-71-1
Solubility:	DMSO up to 10 mM
Chemical Name:	4,4'-((1E,1'E)-(4,6-dinitro-1,3-phenylene)bis(ethene-2,1-diyl))bis(1,2-dichlorobenzene)
Storage:	Powder: 4^oC 1 year. DMSO: 4^oC 3 month; -20^oC 1 year.

Biological Activity:

NSC636819 is a cell permeable and selective novel active-site KDM4A/KDM4B inhibitor with IC50 ~6.4 μM for KDM4A and 9.3 μM for KDM4B. It inhibits histone demethylase activity on H3K9me3 and induces apoptosis in LNCaP prostate cancer cells in vitro. It also negatively regulates androgen-responsive genes. The overexpression of KDM4A/KDM4B in prostate cancer and their association with androgen receptor suggest that KDM4A/KDM4B are potential progression factors for prostate cancer.

How to Use:

In vitro: NSC636819 was used at 10 µM final concentration in vitro and in cellular assays.
In vivo: n/a

Reference:

1. Chu CH, et al. KDM4B as a target for prostate cancer: structural analysis and selective inhibition by a novel inhibitor. (2014) J Med Chem. 57(14):5975-85.

Products are for research use only. Not for human use.

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