Biological Activity:Napabucasin (BBI608) is a potent and selective STAT3 inhibitor. It can inhibit gene transcription driven by Stat3 and cancer stemness properties, can inhibit stemness gene expression and block spherogenesis of or kill stemness-high cancer cells isolated from a variety of cancer types (IC50 ~0.14-1.25 µM), but not hematopoietic stem cells. Napabucasin inhibits PaCa-2 xenograft tumor growth in mice, even after cessation of treatment, and decreases population of CSCs in PaCa-2 tumors from treated mice. How to Use:In vitro: Napabucasin (BBI608) was used at 0.5-2 µM final concentration in various assays. In vivo: Napabucasin (BBI608) can be dosed to mice at 50 mg/Kg by IP injection once per day in xenograft models. Reference:
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