LMK235,HDAC4andHDAC5Inhibitor

LMK235 is a potent and selective histone deacetylase HDAC4 and HDAC5 inhibitor  (IC₅₀ ~11.9 nM and 4.22 nM respectively).  It also has inhibitory activities against HDAC 6, 1, 11, 2, and 8 with IC₅₀ for 55.7, 320, 852, 881, and 1278 nM, respectively. LMK235 exhibits cytotoxity against chemo-resistant cancer cell lines in human ovarian cancer cell lines A2780 and cisplatin resistant A2780CisR (IC₅₀ ~0.49 and 0.32 μM respectively). 

How to Use: 

• In vitro:  LMK235 was used at 1 µM final concentration in vitro and in cellular assays.
• In vivo: n/a

Reference:

• 1. Marek L, et al. Histone deacetylase (HDAC) inhibitors with a novel connecting unit linker region reveal a selectivity profile for HDAC4 and HDAC5 with improved activity against chemoresistant cancer cells. (2013) J Med Chem. 56(2):427-36. 

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