J147,NeuroprotectiveSmallMolecule

J147 is a potent and orally active neurotrophic molecule discovered based upon efficacy in multiple cellular models of age-associated pathologies rather than exclusively amyloid metabolism. J147 is broadly neuroprotective, and active in six different assays that represent distinct neurotoxicity pathways related to aging and neurodegenerative diseases, with EC₅₀ between 10 and 200 nM. It can also improve memory in normal rodents, and prevent the loss of synaptic proteins and cognitive decline in a transgenic AD mouse model.

How to Use: 

• In vitro:  J147 was used at 1 µM in vitro and in cellular assays.
• In vivo: J147 was orally dosed to mice at 1-5 mg/kg once per day. Or the transgenic mice were fed with J147 in their chow at 200 ppm starting at 4 months of age. 

Reference:

• 1. Chen Q, et al. A novel neurotrophic drug for cognitive enhancement and Alzheimer's disease. (2011) PLoS One. 6(12):e27865.
• 2. Chiruta C, et al. Metabolism of a potent neuroprotective hydrazide. (2013) Bioorg Med Chem. 21(10):2733-41.
• 3. Prior M, et al. The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer's disease mice.  (2013) Alzheimers Res Ther. 5(3):25.

Products are for research use only. Not for human use.