Biological Activity:ISX9 is a neurogenic modulator. It mediates neuroD reporter gene induction via activation of Ca2+ influx, and increases expression of neurogenic differentiation 1 (NeuroD1) transcription factor. It induces neuronal differentiation in human cortical neuronal cells (HCN), ***** mouse whole brain (MWB) and subventricular zone (SVZ) progenitors. ISX9 is also shown to induce cardiomyogenic differentiation of Notch-activated epicardium-derived cells in vitro.How to Use:In vitro: ISX9 was used at 10-20 µM final concentration in vitro and in cellular assays.In vivo: Reference:
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