Biological Activity:
IOX1 is a cell-permeable broad-spectrum inhibitor of most 2OG oxygenases. It inhibits histone demethylase JMJD3, JMJD1A, JMJD2A, JMJD2E, JMJD2C and UTX with IC50 at 0.12, 0.17, 0.2, 0.3, 0.6 and 1 μM respectively. IOX1 inhibits JMJD2A-mediated H3K9me3 demethylation in HeLa cells.
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