Biological Activity:GN44028 is potent and selective HIF-1α inhibitor with IC50 ~14 nM. It inhibits hypoxia-induced HIF-1α transcriptional activity without suppressing HIF-1α mRNA expression, HIF-1α protein accumulation, or HIF-1α/HIF-1β heterodimerization in nuclei under the hypoxic conditions. This suggests that GN44028 probably affected the transcriptional pathway induced by the HIF-1α/HIF-1β heterodimer.How to Use:In vitro: GN44028 was used at 1-10 µM in vitro and cellular assays.In vivo: n/aReference:
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