Biological Activity:
DZNep (3-Deazaneplanocin A, NSC617989) is an S-adenosylhomocysteine hydrolase inhibitor, indirectly inhibiting histone methyltransferases and decreasing global DNA methylation. It competitively inhibits S-adenosylhomocysteine hydrolase (Ki ~50 pM), decreases EZH2 activities, and inhibits trimethylation of lysine 27 on histone H3 in cultured human acute myeloid leukemia (AML) HL-60 and OCI-AML3 cells and in primary AML cells in a dose-dependent manner (IC50 ~0.2-1 μM). In vivo it shows strong anticancer activity by IP injection alone or in combination with the pan-histone deacetylase inhibitor panobinostat. DZNep can also enhance Oct 4 expression in generating induced pluripotent stem cells (iPSCs).
How to Use:
Reference:
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