DAPT is a widely used γ-secretase inhibitor and serves as an inhibitor of Notch, a γ-secretase substrate. It can also cause a reduction in Aβ40 and Aβ42 levels in human primary neuronal cells (IC50 ~115 nM for total Aβ and ~200 nM for Aβ42) and in brain extracts, as well as in vivo. Since the Notch pathway is involved in development of many cell types, DAPT is used to modulate Notch activity in ESC/iPSC or ***** stem cell differentiation studies.
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