BRD9757 is a highly potent and selective HDAC6 inhibitor with an IC50 of 30 nM toward HDAC6. It has >20-fold selectivity for class I and > 400-fold selectivity for class II HDACs tested. BRD9757 is absence of a surface-binding motif. It demonstrates that high selectivity and potent inhibition of HDAC6 can be achieved through careful choice of linker element only. BRD9757 can be used as a useful tool for probing the biological functions and relevance of the different HDAC isoforms, and serves as a basis for new selective inhibitors of other HDAC isoforms.
How to Use:
In vitro: BRD9757 was suggested to be used at 10 µM final concentration in vitro and in cellular assays.
In vivo: n/a
Reference:
Products are for research use only. Not for human use.
本公司网站所展示销售的产品仅供科研！
沪公网安备 31011202007337号
