OICR9429,WDR5Antagonist

点击看大图

如果您对该产品感兴趣的话,可以

产品名称: OICR9429,WDR5Antagonist

产品型号: M60255-2s

产品展商: 其它品牌

产品文档: 无相关文档

简单介绍

OICR9429,WDR5Antagonist

OICR9429,WDR5Antagonist 的详细介绍

Product Information

Molecular Weight:	555.59
Formula:	C₂₉H₃₂F₃N₅O₃
Purity:	≥98%
CAS#:	n/a
Solubility:	DMSO up to 50 mM
Chemical Name:	N-(4-(4-methylpiperazin-1-yl)-3'-(morpholinomethyl)-[1,1'-biphenyl]-3-yl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridine-3-carboxamide
Storage:	Powder: 4^oC 1 year. DMSO: 4^oC 3 month; -20^oC 1 year.

Biological Activity:

OICR9429 is a potent and selective WD repeat-containing protein 5 (WDR5) antagonist (Kd ~24-52 nM). It has >100-fold selectivity over other methyltransferases tested. It disrupts WDR5 interaction with peptide regions of MLL and Histone 3. OICR-9429 also disrupts the interaction of WDR5 with MLL1 and RbBP5 in cells with IC50 values below 1 µM.

How to Use:

In vitro: OICR9429 was used at 5-10 µM final concentration in various in vitro assays.
In vivo: n/a

Reference:

1. http://www.thesgc.org/chemical-probes/OICR-9429.

Products are for research use only. Not for human use.

产品留言

标题

联系人

联系电话

内容

验证码

点击换一张

注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
2.如有必要,请您留下您的详细联系方式!