Biological Activity:MSAB is a potent and selective Wnt/β-catenin inhibitor identified using cell-based chemical screening. It binds to β-catenin, promoting its degradation, and specifically downregulates Wnt/β-catenin target genes. MSAB shows potent anti-tumor effects selectively on Wnt-dependent cancer cells in vitro and in mouse cancer models.How to Use:In vitro: MSAB was suggested to be used at 5-10 µM final concentration in vitro. In vivo: MSAB was used to dose mice at 10-20 mg/kg by intraperitoneal injection once per day in xenograft model of HCT116, HCT115 and H23 cell lines, and MMTV-Wnt1 transgenic mice. Reference:
本公司网站所展示销售的产品仅供科研!
沪公网安备 31011202007337号