GNF-7,RasSignalingInhibitor

Biological Activity:

GNF-7 is a potent, selective and bioavailable Ras signaling inhibitor. It inhibits Ack1 and germinal center kinase (GCK). It can suppress proliferation, and induce cell cycle arrest and apoptosis in leukemia cells harboring NRAS mutations. In vivo GNF-7 showed good efficacy in a xenotransplantation model and activity against primary AML patient samples.

How to Use:

In vitro: GNF-7 was used at 1 µM final concentration in vitro and in cellular assays.
In vivo: GNF-7 was orally dosed to MOLT-3 xenotransplantation model at 7.5-15 mg/Kg once a day.

Reference:

• 1. Nonami A., et al. Identification of novel therapeutic targets in acute leukemias with NRAS mutations using a pharmacologic approach. (2015) Blood. 125(20):3133-43. 

产品留言

标题

联系人

联系电话

内容

验证码

点击换一张

注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
2.如有必要,请您留下您的详细联系方式!