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Conantokin-G Selective inhibitor of NR2B-containing NMDAR

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产品名称: Conantokin-G Selective inhibitor of NR2B-containing NMDAR
产品型号: 08CON009-00500
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Conantokin-G Selective inhibitor of NR2B-containing NMDAR Conantokin-G is a conopeptide that has been isolated from the venom of the cone Conus geographus. Conantokin-G selectively inhibits NR2B containing N-methyl-D-aspartate receptors (NMDAR) with a high specificity. Thus, Conantokin-G inhibits in a concentration-dependent manner the Ca2+ influx leading to a neuroprotective effect against NMDA-


Conantokin-G Selective inhibitor of NR2B-containing NMDAR  的详细介绍
Conantokin-G Selective inhibitor of NR2B-containing NMDAR Conantokin-G is a conopeptide that has been isolated from the venom of the cone Conus geographus. Conantokin-G selectively inhibits NR2B containing N-methyl-D-aspartate receptors (NMDAR) with a high specificity. Thus, Conantokin-G inhibits in a concentration-dependent manner the Ca2+ influx leading to a neuroprotective effect against NMDA-induced excitotoxicity. Conantokin-G was shown to block NMDA-evoked currents in murine cortical neurons with an IC50 value of around 480 nM.
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