产品资料

Hainantoxin-IV Potent blocker of voltage-gated sodium channels

如果您对该产品感兴趣的话,可以
产品名称: Hainantoxin-IV Potent blocker of voltage-gated sodium channels
产品型号: 12HTX001-00100
产品展商: 其他品牌
产品文档: 无相关文档

简单介绍

Hainantoxin-IV Potent blocker of voltage-gated sodium channels Hainantoxin-IV (HNTX-IV) is a peptide that was originally isolated from the venom of the Chinese bird spider Ornithoctonus hainana Liang (Selenocosmia hainana Liang). It has been reported that this peptide is a potent antagonist of tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channels (VGSCs). Hainantoxin-IV binds to TTX-S with


Hainantoxin-IV Potent blocker of voltage-gated sodium channels  的详细介绍
Hainantoxin-IV Potent blocker of voltage-gated sodium channels Hainantoxin-IV (HNTX-IV) is a peptide that was originally isolated from the venom of the Chinese bird spider Ornithoctonus hainana Liang (Selenocosmia hainana Liang). It has been reported that this peptide is a potent antagonist of tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channels (VGSCs). Hainantoxin-IV binds to TTX-S with an IC50value of 34 nM in ***** rat dorsal root ganglion (DRG) neurons. Tetrodotoxin-resistant (TTX-R) voltage-gated sodium channels are not affected by Hainantoxin-IV. It probably interacts with the site 1 through a mechanism quite similar to that of TTX without affecting the activation and inactivation kinetics.
产品留言
标题
联系人
联系电话
内容
验证码
点击换一张
注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
2.如有必要,请您留下您的详细联系方式!
相关产品
Morphiceptin Agonist of µ-opoid receptor 11CAS001-01000
Melittin Highly pure synthetic Melittin MEL01
Lys-conopressin-G Vasopressin-like peptide 11CON014-00500
Cy3-Crotamine Fluorescent tumor-cell specific agent CRO002
Crotamine Cell-penetrating peptide and ion channels blocker CRO001
Conantokin-G Selective inhibitor of NR2B-containing NMDAR 08CON009-00500
Purotoxin-1 Selective inhibitor of P2X3 receptors 011PUR001-00100
Obtustatin Inhibitor of the binding of α1β1 integrin to collagen IV 10OBT001-00100
Echistatin α1 isoform ECH001
ρ-Da1a – AdTx1 Selective antagonist of the alpha(1A)-adrenoceptor ADT001-00010
Rho-Conotoxin-TIA Blocker of α1-adrenoreceptor CON022-00100
MT7 – Muscarinic Toxin 7 Blocker of M1-subtype of muscarinic receptor MTX007-00100
NMB-1 NMB001-00100
GsMTx4 Selective blocker of mechanosensitive ion channels 08GSM001-00050
Psalmotoxin-1 / PcTx1 ASIC1a selective blocker 13PCT001-00100
MitTx MitTx toxin – ASIC1a/1b agonist MTX002
Mambalgin-1 ASIC1a & 1b channel blocker MAM001-50010
APETx2 ASIC3 selective inhibitor 07APE002-00100
αC-Conotoxin-PrXA Selective blocker of muscular nACh receptors 13CON016-00100
α-conotoxin-PeIA Discriminates between α9α10 and α7 nAChRs 13CON017-00100
α-conotoxin-MI Blocks the α/δ site of the muscle-type nAChR 08CON012-00500
α-conotoxin-IMI α7 nAChR selective blocker 08CON011-00500
α-conotoxin-GID Blocker of α3β2, α7 and α4β2 nAChRs CON019-50100
α-conotoxin-GI Blocks the α/δ site of the muscle-type nAChR 08CON015-00500
α-Conotoxin PIA CON023
α-Conotoxin BuIA CON024-00100
Waglerin-1-FAM Waglerin-1 blocks muscle nAChRs WAG002-01000
Waglerin-1 Waglerin-1 blocks muscle-type nAChRs 12WAG001-01000
alpha-cobratoxin α7 nicotinic acetylcholine receptor (nAChR) antagonist CBT001
GaTx2 Selective blocker of ClC2 (CLCN2) chloride channels 10GTX002-00100

沪公网安备 31011202007337号