TAMix - Mix of S.typhimurium Tester Strains for Ames Test

• for screening of chemical, pharmaceutical or cosmetic test compounds in a miniaturized Ames test system (Ames II) 
• for the detection of genotoxic impurities according to ICH M7 Guideline
• for testing waste or surface water according to ISO ISO 11350:2012. 

Characteristics

• TA7001, TA7002, TA7003, TA7004, TA7005, TA7006, responsive to each of the several possible base-pair substitution events.
• Mutations: TA7001 hisG1775;  TA7002 hisC9138; TA7003 hisG9074; TA7004 hisG9133; TA7005 hisG9130; TA7006 hisC9070       
• Type: All Base Pair Substitution  
• Target: TA7001 A:T>G:C; TA7002 T:A>A:T; TA7003  T:A>G:C;  TA7004 G:C>A:T; TA7005 C:G>A:T; TA7006 C:G>G:C
• rfa Mutation: defective lipopolysaccharide (LPS) layer
• uvrB Mutation: Eliminates the accurate excision repair mechanism
• pKM101 R-Factor Plasmid: Enhances chemical and UV-induced mutagenesis, Ampicilline Resistance
• Frozen, liquid formulation, shipment on dry ice

Safety

The strains of Salmonella typhimurium and Escherichia coli are classified under the lowest level of risk, groupe 1 in Switzerland, Biostoff S1 in Germany, ... They are considered as non-GMOs because they can be constructed by self-cloning or are naturally occurring bacterial strains. They do not disturb the biological diversity.