Biological Activity:TZ9 is a selective and cell permeable inhibitor of human E2 ubiquitin-conjugating enzyme Rad6B. It binds to the Rad6B catalytic site, inhibits Rad6B-induced histone H2A ubiquitination, downregulates intracellular β-catenin. It can induce G2/M arrest and apoptosis, and inhibit proliferation and migration of metastatic human breast cancer cells (IC50 ~6 µM).How to Use:In vitro: TZ9 was used at 10-50 µM final concentration in vitro and in cellular assays.In vivo: n/a Reference:
本公司网站所展示销售的产品仅供科研!
沪公网安备 31011202007337号