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HistoneH3K79me1PolyclonalAntibody

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产品名称: HistoneH3K79me1PolyclonalAntibody
产品型号: A70019-5
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HistoneH3K79me1PolyclonalAntibody


HistoneH3K79me1PolyclonalAntibody  的详细介绍
Product Information
Purity: Affinity purification
Storage: Store at -20 or -80°C. Avoid freeze/thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Catalog No: A70019

Histone H3K79me1 Polyclonal Antibody

Application:

WB (1:500-1:2000), IHC (1:50-1:200), IF (1:50-1:200), IP (1:50-1:200), ChIP (1:50-1:200)

Cross-Reactivity: H, M, R, other (wide range)

Calculated MW: 15kDa

Species: Rabbit

Isotype: IgG

Purity: Affinity purification

Concentration: 1mg/mL

Storage:

Store at -20 or -80°C. Avoid freeze/thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Immunogen Information

Immunogen:

A synthetic methylated peptide corresponding to residues surrounding Lys79 of human histone H3

Gene ID: 8290

Swiss Prot: Q16695

Synonyms:

HIST1H3J; H3/j; H3FJ; Histone H3.1; Histone H3/a; Histone H3/b; Histone H3/c; Histone H3/d; Histone H3/f; Histone H3/h; Histone H3/I; Histone H3/j; Histone H3/k; Histone H3/I; HIST3H3

Background:
H3K79 methylation is one of the gene activation markers.  DOT1L methyltransferase usually involves in H3K79 methylation, playing essential roles in embryonic development, hematopoiesis, cardiac function and the development of leukemia.

To detect marker H3K79 methylation status, pick from our H3K79 polyclonal antibody series.

PDF:

SDS:

Reference:

1. Robert A Copeland. Protein methyltransferases in cancer. (2013) AACR Annual Meeting.

2. Roy M Pollock. Preclinical Characterization of a Potent, Selective Inhibitor of the Protein Methyltransferase DOT1L for Use in the Treatment of MLL-Rearranged Leukemia. (2012) 54th ASH Annual Meeting and Exposition. 

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