Monomethyl auristatin F (MMAF) is an anti-mitotic agent that inhibits cell division by blocking the polymerization of tubulin. It is a new auristatin derivative ith a charged C-terminal phenylalanine residue that attenuates its cytotoxic activity compared to its uncharged counterpart MMAE. Because of its super toxicity, it cannot be used as a drug itself. It is linked to a monoclonal antibody (mAb) that directs it to the cancer cells. The linker to the monoclonal antibody is stable in extracellular fluid, but is cleaved by cathepsin once the conjugate has entered a tumor cell, thus activating the anti-mitotic mechanism.
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