Biological Activity:CB-5083 is a highly potent, selective and orally bioavailable p97 AAA ATPase inhibitor with IC50 ~11 nM. Treatment of tumor cells with CB-5083 leads to accumulation of poly-ubiquitinated proteins, retention of endoplasmic reticulum-associated degradation (ERAD) substrates, and generation of irresolvable proteotoxic stress, leading to activation of the apoptotic arm of the unfolded protein response. In xenograft models, CB-5083 causes modulation of key p97-related pathways, induces apoptosis, and has antitumor activity in a broad range of both hematological and solid tumor models.How to Use:In vitro: CB-5083 was used at 1-2.5 µM final concentration in various assays. In vivo: CB-5083 was dosed to mice orally at 25-100 mg/Kg once or twice per day. Reference:
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