Biological Activity:
BAZ2-ICR is a potent and selective BAZ2 bromodomain inhibitor with Kd values of 109 and 170 nM for BAZ2A and BAZ2B, respectively. It exhibits 15-fold selectivity for the BAZ2 bromodomain over the CERC2 bromodomain and >100-fold selectivity over a range of other bromodomains. It shows accelerated FRAP recovery at 1 µM in the BAZ2A FRAP assay.
How to Use:
In vitro: BAZ2-ICR was used at 1-10 µM final concentration in various in vitro assays.
In vivo: n/a
Reference:
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