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Recombinant Human Stromal cell-derived factor 1 protein(CXCL12) (Active)

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产品名称: Recombinant Human Stromal cell-derived factor 1 protein(CXCL12) (Active)
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Recombinant Human Stromal cell-derived factor 1 protein(CXCL12) (Active)


Recombinant Human Stromal cell-derived factor 1 protein(CXCL12) (Active)  的详细介绍
  • 产品类型:
    Chemokine
  • 产品名称:

    Recombinant Human Stromal cell-derived factor 1 protein(CXCL12) (Active)

  • uniprot号:
  • 规格:
    ¥620
  • 图像:
  • 基因名称:
    CXCL12
  • 别名:
    SDF-1, C-X-C motif chemokine 12, Intercrine reduced in hepatomas, IRH, hIRH
  • 种属:
    Homo sapiens (Human)
  • 蛋白描述:
    Partial of Isoform Gamma
  • PubMed ID:
    7490086; 16626895; 14702039; 16344560; 15164054; 15489334; 8752281; 9427609; 10446158; 11069075; 11859124; 14525775; 16107333; 15741341; 16725153; 18802065; 19255243; 22457824; 9384579; 9618518; 10954912; 15588815; 17264079; 17357154; 18799424; 19551879; 20077567
  • 分子量:
    11.6 kDa
  • 标签信息:
    Tag-Free
  • 来源:
    E.Coli
  • 纯度:
    >96% as determined by SDS?PAGE and HPLC.
  • 缓冲液:
    0.2 μm filtered PBS, pH 7.4 ,lyophilized
  • 内毒素:
    Less than 1.0 EU/μg as determined by LAL method.
  • 生物活性:
    Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using PHA and rHuIL?2 activated human peripheral blood T?lymphocytes is in a concentration range of 30?100 ng/ml.
  • Uniprot登录名:
    SDF1_HUMAN
  • 参考文献:
    Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation. {ECO:0000269|PubMed:11069075, ECO:0000269|PubMed:11859124, ECO:0000269|PubMed:16107333, ECO:0000269|PubMed:18802065, ECO:0000269|PubMed:19255243, ECO:0000269|PubMed:8752281}.
  • 氨基酸序列:
    GKPVSLSYRC PCRFFESHVA RANVKHLKIL NTPNCALQIV ARLKNNNRQV CIDPKLKWIQ EYLEKALNKG RREEKVGKKE KIGKKKRQKK RKAAQKRKN
  • 表达区域:
    21-119aa
  • 研究领域:
    Immunology
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