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Recombinant Human C-C motif chemokine 5 protein(CCL5) (Active)
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产品名称:
Recombinant Human C-C motif chemokine 5 protein(CCL5) (Active)
产品型号:
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简单介绍
Recombinant Human C-C motif chemokine 5 protein(CCL5) (Active)
Recombinant Human C-C motif chemokine 5 protein(CCL5) (Active)
的详细介绍
产品类型:
Chemokine
产品名称:
Recombinant Human C-C motif chemokine 5 protein(CCL5) (Active)
uniprot号:
规格:
5μg
20μg
100μg
250μg
¥620
图像:
基因名称:
CCL5
别名:
EoCP, SIS-delta, Small-inducible cytokine A5, T cell-specific protein P228, TCP228
种属:
Homo sapiens (Human)
蛋白描述:
Full Length of Mature Protein
PubMed ID:
2456327; 10213461; 16791620; 15489334; 1380064; 7524281; 8525373; 9516414; 15923218; 17001303; 23979485; 7537088; 7542919; 9889151;
分子量:
7.8 kDa
标签信息:
Tag-Free
来源:
E.Coli
纯度:
>98% as determined by SDS-PAGE and HPLC.
缓冲液:
0.2 μm filtered PBS, pH 7.4 ,lyophilized
内毒素:
Less than 1.0 EU/μg as determined by LAL method.
生物活性:
Fully
biolog
ically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human peripheral blood monocytes is in a concentration range of 1.0-10 ng/ml.
Uniprot登录名:
CCL5_HUMAN
参考文献:
Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils (PubMed:16791620, PubMed:1380064, PubMed:8525373, PubMed:9516414, PubMed:15923218). May also be an agonist of the G protein-coupled receptor GPR75, stimulating inositol trisphosphate production and calcium mobilization through its activation. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells (PubMed:23979485). {ECO:0000269|PubMed:1380064, ECO:0000269|PubMed:15923218, ECO:0000269|PubMed:16791620, ECO:0000269|PubMed:17001303, ECO:0000269|PubMed:23979485, ECO:0000269|PubMed:8525373, ECO:0000269|PubMed:9516414}.
氨基酸序列:
SPYSSDTTPC CFAYIARPLP RAHIKEYFYT SGKCSNPAVV FVTRKNRQVC ANPEKKWVRE YINSLEMS
表达区域:
24-91aa
研究领域:
Immunology
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