Colony Stimulating Factor

CSF1

CSF-1, MCSF, Lanimostim

Homo sapiens (Human)

Partial

2996129; 3493529; 2460758; 2660794; 14702039; 16710414; 15489334; 3500041; 1791839; 8262907; 3498652; 3259875; 3039346; 3264877; 1531650; 8422357; 15519852; 16337366; 18687298; 19934330; 20829061; 20504948; 22171320; 23234360; 26091039; 1455231

36.8 kDa

Tag-Free

E.Coli

>95% as determined by SDS-PAGE and HPLC.

0. 2um filtered PBS, pH7.4 ,lyophilized

Less than 1.0 EU/μg as determined by LAL method.

Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine M-NFS-60 cells is less than 1 ng/ml, corresponding to a specific activity of >1.0x10⁶ IU/mg.

CSF1_HUMAN

Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance. {ECO:0000269|PubMed:16337366, ECO:0000269|PubMed:19934330, ECO:0000269|PubMed:20504948, ECO:0000269|PubMed:20829061}.

EEVSEYCSHM IGSGHLQSLQ RLIDSQMETS CQITFEFVDQ EQLKDPVCYL KKAFLLVQDI MEDTMRFRDN TPNAIAIVQL QELSLRLKSC FTKDYEEHDK ACVRTFYETP LQLLEKVKNV FNETKNLLDK DWNIFSKNCN NSFAECSSQG HERQSEGS

33-181aa

Immunology