Interleukin

IL4

IL-4, BSF-1, Lymphocyte stimulatory factor 1

Macaca mulatta (Rhesus macaque)

Full Length of Mature Protein

7561102

14.9 kDa

Tag-Free

E.Coli

>96% as determined by SDS-PAGE and HPLC.

0.2 μm filtered 2 x PBS, pH 7.4, 5 % trehalose ,lyophilized

Less than 1.0 EU/μg as determined by LAL method.

Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using human TF-1 cells is less than 1.0 ng/ml, corresponding to a specific activity of >1.0x10⁶ IU/mg.

IL4_MACMU

Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes (By similarity). {ECO:0000250}.

HNCHIALREI IETLNSLTEQ KTLCTKLTIT DILAASKNTT EKETFCRAAT VLRQFYSHHE KDTRCLGATA QQFHRHKQLI RFLKRLDRNL WGLAGLNSCP VKEANQSTLE DFLERLKTIM REKYSKCSS

25-153aa

Immunology