Interleukin

IL16

IL-16, LCF,]

Homo sapiens (Human)

Partial

12923170; 19906316; 14702039; 16572171; 15489334; 9990060; 8609984; 7910967; 9422780; 11032842; 11276202; 12450396; 12620798; 14734747; 18097041; 21269460; 24275569; 9699630;

13.4 kDa

Tag-Free

E.Coli

>95% as determined by SDS-PAGE and HPLC.

0.2 μm filtered PBS, pH 7.4, lyophilized

Less than 1.0 EU/μg as determined by LAL method.

Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine D10S cells is less than 1.0 pg/ml, corresponding to a specific activity of >1.0x10⁹ IU/mg.

IL16_HUMAN

Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.; Isoform 1 may act as a scaffolding protein that anchors ion channels in the membrane.; Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.

MPDLNSSTDS AASASAASDV SVESTAEATV CTVTLEKMSA GLGFSLEGGK GSLHGDKPLT INRIFKGAAS EQSETVQPGD EILQLGGTAM QGLTRFEAWN IIKALPDGPV TIVIRRKSLQ SKETTAAGDS

1203-1332aa

Immunology