Growth Factor

PDGFB

PDGF subunit B, Platelet-derived growth factor B chain, Platelet-derived growth factor beta polypeptide, Proto-oncogene c-Sis, Becaplermin

Homo sapiens (Human)

Full Length of Mature Protein

6740330; 4033772; 2991848; 3472769; 3517869; 15461802; 10591208; 15489334; 7659502; 8988177; 6327048; 3456904; 6306471; 6844921; 6329745; 1661670; 1317862; 11331882; 12660034; 18483217; 1396586; 20534510; 23913003

24.8 kDa

Tag-Free

E.Coli

>97% as determined by SDS-PAGE and HPLC.

0.2 μm filtered PBS, pH 7.4 ,lyophilized

Less than 1.0 EU/μg as determined by LAL method.

Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine Balb/c 3T3 cells is less than 3 ng/ml, corresponding to a specific activity of >3.3x10⁵ IU/mg.

PDGFB_HUMAN

Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA (By similarity). {ECO:0000250}.

M+SLGSLTIAE PAMIAECKTR TEVFEISRRL IDRTNANFLV WPPCVEVQRC SGCCNNRNVQ CRPTQVQLRP VQVRKIEIVR KKPIFKKATV TLEDHLACKC ETVAAARPVT

82-190aa

Cancer