Tumor Necrosis Factor

Tnf

Cachectin, Tumor necrosis factor ligand superfamily member 2, TNF-a, , NTF

Mus musculus (Mouse)

Partial

2836146; 3898078; 2419912; 2989794; 3040015; 3684584; 7560085; 9089109; 14656967; 2777790; 2268312; 3349526; 10089307

17.4 kDa

Tag-Free

E.Coli

>98% as determined by SDS-PAGE and HPLC.

0.2 μm filtered PBS, pH 7.2 ,lyophilized

Less than 1.0 EU/μg as determined by LAL method.

Fully biologically active when compared to standard. The ED50 as determined by a cytotoxicity assay using murine L929 cells is less than 0.1 ng/ml, corresponding to a specific activity of >1.0x10⁷ IU/mg in the presence of actinomycin D.

TNFA_MOUSE

Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation.; The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells. {ECO:0000250}.

M+LRSSSQNSS DKPVAHVVAN HQVEEQLEWL SQRANALLAN GMDLKDNQLV VPADGLYLVY SQVLFKGQGC PDYVLLTHTV SRFAISYQEK VNLLSAVKSP CPKDTPEGAE LKPWYEPIYL GGVFQLEKGD QLSAEVNLPK YLDFAESGQV YFGVIAL

80-235aa

Cancer