Growth Factor

PTN

PTN, HBBM, Heparin-binding growth factor 8, HBGF-8, Heparin-binding growth-associated molecule

Homo sapiens (Human)

Full Length of Mature Protein

1701634; 2270483; 1768439; 1457401; 8484754; 9299545; 14702039; 12690205; 15489334; 2388713; 1733956; 8241100; 8484780; 11278720; 20873783

15.3 kDa

Tag-Free

E.Coli

>96% as determined by SDS?PAGE and HPLC.

0.2 m filtered PBS, pH 7.4 ,lyophilized

Less than 1.0 EU/μg as determined by LAL method.

Fully biologically active when compared to standard. The biological activity was measured by its ability to enhance neurite outgrowth of E16?E18 rat embryonic cortical neurons, when neurons were plated on 96 well culture plates that had been pre?coated with 100 ?l/well of a solution of 5?10 ug/ml rHuPTN.

PTN_HUMAN

Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation. {ECO:0000269|PubMed:11278720, ECO:0000269|PubMed:1768439}.

GKKEKPEKKV KKSDCGEWQW SVCVPTSGDC GLGTREGTRT GAECKQTMKT QRCKIPCNWK KQFGAECKYQ FQAWGECDLN TALKTRTGSL KRALHNAECQ KTVTISKPCG KLTKPKPQAE SKKKKKEGKK QEKMLD

33-168aa

Immunology