Other

SPARC

Basement-membrane protein 40, Osteonectin, ON, Secreted protein acidic and rich in cysteine

Homo sapiens (Human)

Partial

3410046; 2838412; 2790009; 2338025; 15489334; 17974005; 3597437; 2306517; 3400777; 7495300; 9457905; 8548457; 9233787; 9501084

32.7 kDa

Tag-Free

E.Coli

>98% as determined by SDS-PAGE and HPLC.

0.2 μm filtered PBS, pH 7.4. ,lyophilized

Less than 1.0 EU/μg as determined by LAL method.

Fully biologically active when compared to standard. The ED50 as determined by its ability to inhibit the cell growth of Mv1Lu mink lung epithelial cells is less than 3.0 ug/mL, corresponding to a specific activity of >333 IU/mg.

SPRC_HUMAN

Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium s; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.

APQQEALPDE TEVVEETVAE VTEVSVGANP VQVEVGEFDD GAEETEEEVV

AENPCQNHHC KHGKVCELDE NNTPMCVCQD PTSCPAPIGE FEKVCSNDNK

TFDSSCHFFA TKCTLEGTKK GHKLHLDYIG PCKYIPPCLD SELTEFPLRM

RDWLKNVLVT LYERDEDNNL LTEKQKLRVK KIHENEKRLE AGDHPVELLA

RDFEKNYNMY IFPVHWQFGQ LDQHPIDGYL SHTELAPLRA PLIPMEHCTT

RFFETCDLDN DKYIALDEWA GCFGIKQKDI

18-297aa

Cancer