首页品牌 ELISA试剂盒抗体抗原公司新闻技术文章关于拜力留言询价

产品资料

首页 >>> 产品目录 >>> 蛋白库

Recombinant Human Tumor necrosis factor protein(TNF) (Active)

点击看大图

如果您对该产品感兴趣的话,可以

产品名称: Recombinant Human Tumor necrosis factor protein(TNF) (Active)

产品型号:

产品展商: 其它品牌

产品文档: 无相关文档

简单介绍

Recombinant Human Tumor necrosis factor protein(TNF) (Active)

Recombinant Human Tumor necrosis factor protein(TNF) (Active) 的详细介绍

产品类型:

Tumor Necrosis Factor

产品名称:

Recombinant Human Tumor necrosis factor protein(TNF) (Active)

uniprot号:

规格:

￥620

图像:

基因名称:

TNF

别名:

Cachectin, Tumor necrosis factor ligand superfamily member 2, TNF-a, , NTF

种属:

Homo sapiens (Human)

蛋白描述:

Partial

PubMed ID:

3555974; 6392892; 3883195; 2995927; 3856324; 3932069; 8499947; 10202016; 14656967; 15489334; 8631363; 8597870; 10205166; 2009860; 1402651; 9034191; 10369255; 16829952; 16829951; 22517918; 23396208; 2922050; 1964681; 2551905; 9488135; 9442056; 12746914; 12915457

分子量:

18.3 kDa

标签信息:

N-terminal 6xHis-tagged

来源:

E.Coli

纯度:

>97% as determined by SDS-PAGE and HPLC.

缓冲液:

0.2 m filtered PBS, pH 7.0 ,lyophilized

内毒素:

Less than 1.0 EU/μg as determined by LAL method.

生物活性:

Fully biologically active when compared to standard. The ED50 as determined by a cytotoxicity assay using murine L929 cells is less than 0.05 ng/ml, corresponding to a specific activity of >2.0x10⁷ IU/mg in the presence of actinomycin D.

Uniprot登录名:

TNFA_HUMAN

参考文献:

Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Upregulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Key mediator of cell death in the anticancer action of BCG-stimulated neutrophils in combination with DIABLO/SMAC mimetic in the RT4v6 bladder cancer cell line (PubMed:22517918). {ECO:0000269|PubMed:16829952, ECO:0000269|PubMed:22517918, ECO:0000269|PubMed:23396208}.; The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells. {ECO:0000269|PubMed:16829952}.

氨基酸序列:

MHHHHHH+VRS SSRTPSDKPV AHVVANPQAE GQLQWLNRRA NALLANGVEL RDNQLVVPSE GLYLIYSQVL FKGQGCPSTH VLLTHTISRI AVSYQTKVNL LSAIKSPCQR ETPEGAEAKP WYEPIYLGGV FQLEKGDRLS AEINRPDYLD FAESGQVYFG IIAL

表达区域:

77-233aa

研究领域:

Cancer

产品留言

标题

联系人

联系电话

内容

验证码

点击换一张

注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
2.如有必要,请您留下您的详细联系方式!