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AGScientific
WP1066
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产品名称:
WP1066
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简单介绍
CAS:857064-38-1Formula:C17H14BrN3OMW:356.22Appearance:Off-WhiteSolidPurity:97%byHPLC
WP1066
的详细介绍
A potent, cell-permeable JAK2 inhibitor. A novel analog of the JAK2 inhibitor AG490 (Cat. No. 1570-5) that blocks STAT3 and phosphoinositide-3-kinase pathways. It is significantly more potent and active against human malignant glioma cells in vitro and in vivo than AG 490. Similar to AG490, WP1066 inhibits the phosphorylation of JAK2, but unlike AG490, WP1066 also degrades JAK2 protein, thus blocking its downstream signal transducer and activator of transcription (STAT) and phosphoinositide-3-kinase pathways to results in the activation of the caspase pathway.
Additional Information
Synonyms
(2E)-3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylethy]-2-propenamide
Product #
W-2483
CAS #
857064-38-1
Chemical Name
(2E)-3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylethy]-2-propenamide
Formula
C
17
H
14
BrN
3
O
MW
356.22
Appearance
Off-White Solid
Purity
97% by HPLC
Solubility
DMSO (10 mg/ml) and Ethanol (5 mg/ml)
Melting Point
218.49 °C
Storage Temp
-20°C
Therapeutic Area
Oncological Disorders
Use
A cell permeable inhibitor of STAT3 and JAK-2 protein tyrosine kinase is a potent antitumor agent
Additional Information
MDL Number
MFCD12912450
ChemACX
X4738791-5
InChI
InChI=1S/C17H14BrN3O/c1-12(13-6-3-2-4-7-13)20-17(22)14(11-19)10-15-8-5-9-16(18)21-15/h2-10,12H,1H3,(H,20,22)/b14-10+/t12-/m0/s1
SMILES
C[C@@H](C1=CC=CC=C1)NC(=O)/C(=C/C2=NC(=CC=C2)Br)/C#N
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