Wortmannin

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产品名称: Wortmannin

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简单介绍

CAS:19545-26-7Formula:C23H24O8MW:428.4Appearance:Off-WhitetoPaleYellowSolidPurity:98%

Wortmannin 的详细介绍

A fungal metabolite that specifically inhibits phosphatidylinositol 3-kinase (PI-3), mitogen-activated protein kinase(MAPK) and myosin light-chain kinase (MLCK).Glycogen Synthase Kinase-3 Plays a Central Role in Mediating Glucocorticoid-Induced Apoptosis, Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells.Nongenotropic, Anti-Apoptotic Signaling of 1,25(OH)2-Vitamin D3 and Analogs through the Ligand Binding Domain of the Vitamin D Receptor in Osteoblasts and Osteocytes: MEDIATION BY Src, PHOSPHATIDYLINOSITOL 3-, AND JNK KINASES

Additional Information

Synonyms	Wortmannin, Penicillium wortmanni, KY12420, Antibiotic SL-2052
Product #	W-1022
CAS #	19545-26-7
Chemical Name	(1alpha,11alpha)-11-(Acetyloxy)-1- (methoxymethyl)-2-oxaandrosta-5,8-dieno(6,5,4- bc)furan-3,7,17-trione
Formula	C₂₃H₂₄O₈
MW	428.4
Appearance	Off-White to Pale Yellow Solid
Purity	98%
Solubility	Soluble in Methanol and DMSO
Melting Point	240°C
Storage Temp	-20°C
Therapeutic Area	Infectious Diseases
Use	Wortmannin, a fungal metabolite, is a potent and selective inhibitor of PI 3-kinase

Additional Information

Merck Index	Merck Index: 13.10110.2001
MDL Number	MFCD00133927
ChemACX	X1097086-6
InChI	InChI=1S/C23H24O8/c1-10(24)30-13-7-22(2)12(5-6-14(22)25)16-18(13)23(3)15(9-28-4)31-21(27)11-8-29-20(17(11)23)19(16)26/h8,12-13,15H,5-7,9H2,1-4H3/t12-,13+,15+,22-,23-/m0/s1
SMILES	CC(=O)O[C@@H]1C[C@]2([C@@H](CCC2=O)C3=C1[C@@]4(c5c(coc5C3=O)C(=O)O[C@@H]4COC)C)C

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