Withaferin A, WFA

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产品名称: Withaferin A, WFA

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简单介绍

CAS:5119-48-2Formula:C28H38O6MW:470.6Appearance:Whitetooff-whiteSolidPurity:98%(HPLC)

Withaferin A, WFA 的详细介绍

Withaferin A is cell permeable and potent angiogenesis inhibitor from the family of withanolides. Withaferin A inhibits endothelial cells (HUVEC) sproutingin vitro (IC50=12nM) andin vivo. Withaferin A exhibits antitumor, anti-inflammatory, radiosensitizing, and immunosuppressive properties. Our docking results obtained substantiate the hypothesis that Wthaferin Ahas the potential to inhibit the association of chaperone (Hsp90) to its co-chaperone (Cdc37) by disrupting the stability of attachment of Hsp90 to Cdc37. Conclusively our results strongly suggest that withaferin A is a potent anticancer agent as ascertained by its potent Hsp90-client modulating capability. Gliosis is a biological process that occurs during injury repair in the central nervous system and is characterized by the overexpression of the intermediate filaments (IFs) glial fibrillary acidic protein (GFAP) and vimentinWithaferin Abinds to and down-regulates soluble vimentin and GFAP expression to cause cell cycle G/G arrest.Finally, Withaferin A displays neuronal regenerative properties.

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Additional Information

Synonyms	[5,6-Epoxy-4,27-dihydroxy-1-oxowitha-2,24-dienolide], WA, WFA
Product #	W-1042
CAS #	5119-48-2
Chemical Name	[5,6-Epoxy-4,27-dihydroxy-1-oxowitha-2,24-dienolide]
Formula	C₂₈H₃₈O₆
MW	470.6
Appearance	White to off-white Solid
Purity	98% (HPLC)
Solubility	DMSO (20 mg/ml), methanol (10 mg/ml),100% ethanol
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	An antiangiogenesis compound and poteasome inhibitor.Withaferin A exhibits antitumor, anti-inflammatory, radiosensitizing, and immunosuppressive properties

Additional Information

Merck Index	Merck: 14:10048
MDL Number	MFCD10687098
ChemACX	X1710961-6
InChI	InChI=1S/C28H38O6/c1-14-11-21(33-25(32)17(14)13-29)15(2)18-5-6-19-16-12-24-28(34-24)23(31)8-7-22(30)27(28,4)20(16)9-10-26(18,19)3/h7-8,15-16,18-21,23-24,29,31H,5-6,9-13H2,1-4H3/t15-,16-,18+,19-,20-,21+,23-,24+,26+,27-,28+/m0/s1
SMILES	CC1=C(C(=O)O[C@H](C1)[C@@H](C)[C@H]2CC[C@@H]3[C@@]2(CC[C@H]4[C@H]3C[C@@H]5[C@]6([C@@]4(C(=O)C=C[C@@H]6O)C)O5)C)CO

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