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AGScientific
VX-702
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产品名称:
VX-702
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简单介绍
CAS:479543-46-9Formula:C19H12F4N4O2MW:404.32Appearance:WhitesoildPurity:99%byHPLC
VX-702
的详细介绍
A p38 MAP kinase inhibitor. VX-702 dose-dependently inhibited the production of IL-6, IL-1 and TNF (IC= 59, 122 and 99 ng/ml, respectively). Pre-incubation of platelets with VX-702 (1 M) completely or partially inhibited platelet agonist induced p38 activation (IC= 4 to 20 nM).
Additional Information
Synonyms
2-(2,4-Difluorophenyl)-6-(1-(2,6-difluorophenyl)ureido)nicotinamide
Product #
V-2481
CAS #
479543-46-9
Chemical Name
2-(2,4-Difluorophenyl)-6-(1-(2,6-difluorophenyl)ureido)nicotinamide
Formula
C
19
H
12
F
4
N
4
O
2
MW
404.32
Appearance
White soild
Purity
99% by HPLC
Solubility
DMSO
Storage Temp
-20°C
Therapeutic Area
Inflammatory Diseases
Use
VX-702, a novel p38 MAPK inhibitor, in rheumatoid arthritis
Additional Information
MDL Number
MFCD11616590
ChemACX
X1829255-4
InChI
InChI=1S/C19H12F4N4O2/c20-9-4-5-10(14(23)8-9)16-11(18(24)28)6-7-15(26-16)27(19(25)29)17-12(21)2-1-3-13(17)22/h1-8H,(H2,24,28)(H2,25,29)
SMILES
C1=CC(=C(C(=C1)F)N(C2=NC(=C(C=C2)C(=O)N)C3=C(C=C(C=C3)F)F)C(=O)N)F
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